Study of Microrheology of human synovial fluid by Diffusing wave spectroscopy (DWS) (CAT#: STEM-MB-0854-WXH)

Introduction

Synovial fluid, also known as joint fluid, is a thick liquid located between your joints. The fluid cushions the ends of bones and reduces friction when you move your joints. A synovial fluid analysis is a group of tests that checks for disorders that affect the joints. The viscoelastic properties of synovial fluid (SF) are critical to its functions of lubrication and shock-absorption of joints in human body; a change in the viscoelastic properties, even of only a few percents, is often concomitant with arthritis.

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Principle Applications Procedure Materials Notes Related Products

Principle

Diffusing-wave spectroscopy (DWS) is an optical technique derived from dynamic light scattering (DLS) that studies the dynamics of scattered light in the limit of strong multiple scattering. DWS is able to give information about the local dynamics of particle dispersion in a highly turbid medium. It has been widely used in the past to study colloidal suspensions, emulsions, foams, gels, biological media, and other forms of soft matter. If carefully calibrated, DWS allows the quantitative measurement of microscopic motion in a soft material, from which the rheological properties of the complex medium can be extracted via the microrheology approach.
The technique of DWS depends on the scattering of light from highly turbid suspensions. A sample of the suspension is illuminated by light from a laser and the incoming photons are multiply scattered. This scattered light is detected and subjected to autocorrelation analysis.

Applications

• Diffusing Wave Spectroscopy (DWS) is an advanced light scattering technique, which is primarily applied for microrheology and particle sizing.
• DWS has been applied in biomedical and clinical areas, especially in monitoring cerebral blood flow (CBF).

Procedure

1. Sample Preparation
2. Diffusing Wave Spectroscopy Testing
3. Data analysis

Materials

• Diffusing wave spectroscopy (DWS) instrument
• DWS RheoLab

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