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In Vivo Pharmacodynamic Evaluation of Hep G2 Cell Line Based Liver Cancer (CAT#: STEM-AE-0068-LGZ)

Introduction

Liver cancer refers to malignant tumors occurring in the liver, including primary liver cancer and metastatic liver cancer, mostly primary liver cancer. Primary carcinoma of liver is cancer that occurs in liver cells or bile duct cells inside the liver. Primary liver cancer mainly includes hepatocellular carcinoma (HCC), intrahepatic bile duct (ICC) and HCC-ICC mixed pathological types, which differ greatly in pathogenesis, biological behavior, histological morphology, treatment methods and prognosis, among which hepatocellular carcinoma accounts for more than 85%-90%, with high malignancy, strong invasion and metastasis.




Principle

In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.

Applications

Liver Cancer

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

Notes

Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model