Analysis of Lipopolysaccharide Aggregation by Static light scattering (SLS) (CAT#: STEM-MB-0588-WXH)

Introduction

Lipopolysaccharides (LPS) may behave as bacterial endotoxins and their self-aggregation may affect their toxicity. Lipopolysaccharides (LPS) are cell wall components of Gram-negative bacteria. These molecules behave as bacterial endotoxins and their release into the bloodstream is a determinant of the development of a wide range of pathologies. These amphipathic molecules can self-aggregate into supramolecular structures with different shapes and sizes. The formation of these structures occurs when the LPS concentration is higher than the apparent critical micelle concentration (CMCa).